ParkinsonCanadaV1, Main, Exploration, bibRecord, 001D22

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD

Identifieur interne : 001D22 ( Main/Exploration ); précédent : 001D21; suivant : 001D23

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD

Auteurs : T. Van Eimeren [Canada] ; G. Pellecchia [Canada] ; R. Cilia [Canada] ; B. Ballanger [Canada] ; T. D. L. Steeves [Canada] ; S. Houle [Canada] ; J. M. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; A. P. Strafella [Canada]

Source :

Neurology [ 0028-3878 ] ; 2010.

RBID : Pascal:11-0003745

Descripteurs français

Pascal (Inist)
- Jeu pathologique, Pathologie du système nerveux.

English descriptors

KwdEn :
- Adult, Aged, Antiparkinson Agents (pharmacology), Dopamine Agonists (pharmacology), Frontal Lobe (drug effects), Frontal Lobe (physiology), Gambling (diagnosis), Gambling (psychology), Humans, Middle Aged, Nerve Net (drug effects), Nerve Net (physiology), Nervous system diseases, Neural Inhibition (drug effects), Neural Inhibition (physiology), Parkinson Disease (diagnosis), Parkinson Disease (psychology), Pathological gambling, Photic Stimulation (methods), Positron-Emission Tomography (methods), Predictive Value of Tests.
MESH :
- chemical , pharmacology : Antiparkinson Agents, Dopamine Agonists.
- diagnosis : Gambling, Parkinson Disease.
- drug effects : Frontal Lobe, Nerve Net, Neural Inhibition.
- methods : Photic Stimulation, Positron-Emission Tomography.
- physiology : Frontal Lobe, Nerve Net, Neural Inhibition.
- psychology : Gambling, Parkinson Disease.
- Adult, Aged, Humans, Middle Aged, Predictive Value of Tests.

Abstract

Objective: Some patients with Parkinson disease (PD) develop pathological gambling when treated with dopamine agonists (DAs). However, little is known about DA-induced changes in neuronal networks that may underpin this drug-induced change in behavior in vulnerable individuals. In this case-control study, we aimed to investigate DA-induced changes in brain activity that may differentiate patients with PD with DA-induced pathological gambling (gamblers) from patients with PD without such a history (controls). Methods: Following overnight withdrawal of antiparkinsonian medication, patients were studied with H₂¹⁵O PET before and after administration of DA (3 mg apomorphine) to measure changes in regional cerebral blood flow as an index of regional brain activity during a card selection game with probabilistic feedback. Results: We observed that the direction of DA-related activity change in brain areas that are implicated in impulse control and response inhibition (lateral orbitofrontal cortex, rostral cingulate zone, amygdala, external pallidum) distinguished gamblers from controls. DA significantly increased activity in these areas in controls, while gamblers showed a significant DA-induced reduction of activity. Conclusions: We propose that in vulnerable patients with PD, DAs produce an abnormal neuronal pattern that resembles those found in nonparkinsonian pathological gambling and drug addiction. DA-induced disruption of inhibitory key functions-outcome monitoring (rostral cingulate zone), acquisition and retention of negative action-outcome associations (amygdala and lateral orbitofrontal cortex)-together with restricted access of those areas to executive control (external pallidum)-may well explain loss of impulse control and response inhibition in vulnerable patients with PD, thereby fostering the development of pathological gambling.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033606

Affiliations:

Le document en format XML

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</affiliation>
</author>
<author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Movement Disorders Centre Toronto Western Hospital</s1>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Movement Disorders Centre Toronto Western Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviour-Systems Neuroscience, BIB-SN Toronto Western Research Institute</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Division of Brain, Imaging and Behaviour-Systems Neuroscience, BIB-SN Toronto Western Research Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Movement Disorders Centre Toronto Western Hospital</s1>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Movement Disorders Centre Toronto Western Hospital</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>CAMH-PET Centre University of Toronto</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>Dopamine Agonists (pharmacology)</term>
<term>Frontal Lobe (drug effects)</term>
<term>Frontal Lobe (physiology)</term>
<term>Gambling (diagnosis)</term>
<term>Gambling (psychology)</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Nerve Net (drug effects)</term>
<term>Nerve Net (physiology)</term>
<term>Nervous system diseases</term>
<term>Neural Inhibition (drug effects)</term>
<term>Neural Inhibition (physiology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (psychology)</term>
<term>Pathological gambling</term>
<term>Photic Stimulation (methods)</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Predictive Value of Tests</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Dopamine Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gambling</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Frontal Lobe</term>
<term>Nerve Net</term>
<term>Neural Inhibition</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Photic Stimulation</term>
<term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Frontal Lobe</term>
<term>Nerve Net</term>
<term>Neural Inhibition</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Gambling</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Jeu pathologique</term>
<term>Pathologie du   système nerveux</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: Some patients with Parkinson disease (PD) develop pathological gambling when treated with dopamine agonists (DAs). However, little is known about DA-induced changes in neuronal networks that may underpin this drug-induced change in behavior in vulnerable individuals. In this case-control study, we aimed to investigate DA-induced changes in brain activity that may differentiate patients with PD with DA-induced pathological gambling (gamblers) from patients with PD without such a history (controls). Methods: Following overnight withdrawal of antiparkinsonian medication, patients were studied with H<sub>2</sub>
<sup>15</sup>
O PET before and after administration of DA (3 mg apomorphine) to measure changes in regional cerebral blood flow as an index of regional brain activity during a card selection game with probabilistic feedback. Results: We observed that the direction of DA-related activity change in brain areas that are implicated in impulse control and response inhibition (lateral orbitofrontal cortex, rostral cingulate zone, amygdala, external pallidum) distinguished gamblers from controls. DA significantly increased activity in these areas in controls, while gamblers showed a significant DA-induced reduction of activity. Conclusions: We propose that in vulnerable patients with PD, DAs produce an abnormal neuronal pattern that resembles those found in nonparkinsonian pathological gambling and drug addiction. DA-induced disruption of inhibitory key functions-outcome monitoring (rostral cingulate zone), acquisition and retention of negative action-outcome associations (amygdala and lateral orbitofrontal cortex)-together with restricted access of those areas to executive control (external pallidum)-may well explain loss of impulse control and response inhibition in vulnerable patients with PD, thereby fostering the development of pathological gambling.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Van Eimeren, T" sort="Van Eimeren, T" uniqKey="Van Eimeren T" first="T." last="Van Eimeren">T. Van Eimeren</name>
</noRegion>
<name sortKey="Ballanger, B" sort="Ballanger, B" uniqKey="Ballanger B" first="B." last="Ballanger">B. Ballanger</name>
<name sortKey="Ballanger, B" sort="Ballanger, B" uniqKey="Ballanger B" first="B." last="Ballanger">B. Ballanger</name>
<name sortKey="Cilia, R" sort="Cilia, R" uniqKey="Cilia R" first="R." last="Cilia">R. Cilia</name>
<name sortKey="Cilia, R" sort="Cilia, R" uniqKey="Cilia R" first="R." last="Cilia">R. Cilia</name>
<name sortKey="Houle, S" sort="Houle, S" uniqKey="Houle S" first="S." last="Houle">S. Houle</name>
<name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
<name sortKey="Miyasaki, J M" sort="Miyasaki, J M" uniqKey="Miyasaki J" first="J. M." last="Miyasaki">J. M. Miyasaki</name>
<name sortKey="Pellecchia, G" sort="Pellecchia, G" uniqKey="Pellecchia G" first="G." last="Pellecchia">G. Pellecchia</name>
<name sortKey="Pellecchia, G" sort="Pellecchia, G" uniqKey="Pellecchia G" first="G." last="Pellecchia">G. Pellecchia</name>
<name sortKey="Steeves, T D L" sort="Steeves, T D L" uniqKey="Steeves T" first="T. D. L." last="Steeves">T. D. L. Steeves</name>
<name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<name sortKey="Strafella, A P" sort="Strafella, A P" uniqKey="Strafella A" first="A. P." last="Strafella">A. P. Strafella</name>
<name sortKey="Van Eimeren, T" sort="Van Eimeren, T" uniqKey="Van Eimeren T" first="T." last="Van Eimeren">T. Van Eimeren</name>
<name sortKey="Zurowski, M" sort="Zurowski, M" uniqKey="Zurowski M" first="M." last="Zurowski">M. Zurowski</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD

Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD

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	La maladie de Parkinson au Canada (serveur d'exploration)
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